| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan) alters the labeling of blood constituents with technetium-99m
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| Autores: |
Giani,Tania Santos
Paoli,Severo de
Presta,Giuseppe Antonio
Maiworm,Adalgisa Ieda
Santos-Filho,Sebastião David
Brandão-Neto,José
Medeiros,Aldo da Cunha
Fonseca,Adenilson de Souza da
Bernardo-Filho,Mario
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| Data: |
2007-09-01
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| Ano: |
2007
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| Palavras-chave: |
Technetium-99m
Red blood cell
Oxidant agent
Radiobiocomplex
Plasma proteins
Buzhong Yi Qi Wan
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| Resumo: |
Buzhong Yi Qi Wan (Buzhong) is a medicinal herb widely used in Traditional Chinese Medicine to treat the digestive and circulatory systems. Red blood cell and plasma proteins labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this work was to investigate the effects of an aqueous Buzhong extract on the labeling of blood constituents with 99mTc. Heparinized blood (Wistar rats) was incubated in vitro with different Buzhong extract concentrations and 99mTc-labeling was performed. Plasma (P) and blood cells (BC) were separated and soluble (SF-P, SF-BC) and insoluble (IF-P, IF-BC) fractions were isolated. The radioactivity on blood constituents was determined and the percentage of incorporated radioactivity (%ATI) was calculated. Buzhong extract at the highest concentrations used altered significantly (p<0.05) the %ATI in blood constituents. Substances present in the Buzhong extract could alter the cellular membrane and/or generation of free radicals that have oxidant properties modifying the labeling of blood constituents with 99mTc.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600013
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/S1516-89132007000600013
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.50 n.spe 2007
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| Direitos: |
info:eu-repo/semantics/openAccess
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